Because of the frequency of pathogenic variants that affect splicing (22%-30%, more than 1/3 of which are not detected by gDNA sequencing of protein-coding regions), methods that include cDNA sequencing have higher detection rates than methods based solely on analysis of gDNA ( Table 1). Sequence analysis of NF1 genomic DNA ( gDNA) and/or cDNA (complementary DNA, copied from mRNA) is performed in association with gene-targeted deletion analysis. If the phenotypic findings suggest the diagnosis of NF1, single- gene testing may be considered. Many clinical features of NF1 increase in frequency with age, and some individuals who have unequivocal NF1 as adults cannot be diagnosed in early childhood, before these features become apparent. Some individuals diagnosed with NF1 based on clinical criteria do not have a pathogenic variant detectable by current technology. Negative NF1 molecular testing does not rule out a diagnosis of NF1. The criterion is not met by identification of an NF1 variant only in tumor tissue or identification of a germline likely pathogenic variant or variant of uncertain significance. 4.Ī germline NF1 pathogenic variant must be identified for genetic testing to serve as a criterion for diagnosis. Sphenoid wing dysplasia is not a separate criterion in those with ipsilateral orbital plexiform neurofibromas. A diagnosis of mosaic NF1 should be considered if such lesions are present only on one side or in one segment of the body. 2.ĬALMs, intertriginous freckling, cutaneous neurofibromas, and Lisch nodules are usually bilateral in NF1. Moreover, Legius syndrome is much rarer than NF1, and children with Legius syndrome almost always have an affected parent with only CALMs and intertriginous freckling (see Differential Diagnosis). ![]() Ībout half of individuals with Legius syndrome (see Differential Diagnosis) have skin pigmentary features that meet the diagnostic criteria of NF1 (i.e., ≥6 CALMs and axillary or inguinal freckling), but individuals with Legius syndrome do not have neurofibromas, optic pathway gliomas, Lisch nodules, or typical osseous lesions of NF1. The diagnosis of NF1 is established in a proband with two or more of the features described in Suggestive Findings. Individuals with NF1 whole- gene deletions, large or growing plexiform neurofibromas or intracranial tumors, symptomatic vascular disease, progressive osseous lesions, or other serious disease manifestations require more frequent targeted follow up. Begin annual mammography in women at age 30 years with consideration of annual breast MRI in women between ages 30 and 50 years. Surveillance: Annual physical examination by a physician familiar with the disorder ophthalmologic examination annually in children, and regularly but less frequently in adults developmental assessment of children regular blood pressure monitoring MRI for identification and follow up of clinically suspected intracranial or other tumors that are not apparent on physical examination. Individualized developmental and educational interventions may be beneficial, and methylphenidate treatment often benefits individuals with attention-deficit/hyperactivity disorder. Dystrophic scoliosis often requires surgical management, whereas nondystrophic scoliosis can usually be treated conservatively. Treatment of optic gliomas is generally unnecessary as they are usually asymptomatic and clinically stable. ![]() Complete surgical excision, when possible, of malignant peripheral nerve sheath tumors is the treatment of choice chemotherapy may be beneficial in some individuals. Surgical treatment of diffuse or large plexiform neurofibromas is possible but may be associated with damage to involved nerves or adjacent tissues and stimulate growth of residual tumor. Treatment of manifestations: Referral to specialists for treatment of abnormalities of the eye, central or peripheral nervous system, cardiovascular system, lungs, endocrine system, spine, or long bones surgical removal of disfiguring or uncomfortable discrete cutaneous or subcutaneous neurofibromas.
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![]() it can speak naturally, copy the voices of others, read human handwriting, and even genuinely sweat, smell and bleed. The Terminator is a formidable Cyborg assassin and soldier, designed by the military supercomputer Skynet for infiltration and combat duty, towards the ultimate goal of exterminating the Human Resistance. Athena has master martial arts programming and advanced tactical strategic thinking. Athena has superhuman agility, speed (can outrun a truck) and is tough enough to survive being hit full speed by a truck (she sat up seconds later, no dent or permanent damage). In one case, she pried apart the hand of a giant robot (12 feet tall, several tons in weight). ![]() Knowing that when her body fails her self destruct device will go off, she has Frank drop her into the monitor, but not before letting him know that she had loved him as well.Īthena has x-ray vision, and is strong enough to go toe-to-toe with and even rip the heads off adult sized, super strong Audi Anamatronics. Together they defeat Nix and his men, but during the battle Athena jumped in front of Frank Walker and took an energy blast from Governor Nix, saving Frank's life but condeming her own. Together with an adult Frank Walker, they go back to Tomorrowland and try to convince Governor Nix, the head of Plus Ultra, that earth's fate could be avoided, only to discover that Nix is partially to blame for the coming disaster. Now out of work and avoiding disassembly, Athena escapes to earth and seeks out someone who can help fix the Monitor, eventually finding a teenage genius named Casey Newton. Walker soon fell in love with Athena, but grew angry when he discovered that Athena wasn't human.Īfter the Monitor, a machine that can see into the future, predicts an eventually apocalypse, the goal of making a better world is dropped, and soon after in 1984 Frank is banished from Tomorrowland. During the 1964 World's Fair she helped a boy genius named Frank Walker to find Tomorrowland, where he was made a full fledged member. Built at least sometime before 1964, Athena served as a recruiter, finding scientists and artists and leading them to Tomorrowland, Plus Ultra's secret city, located in another universe. The Lethal Childlike Android dedicated to saving the world vs the Cyborg hitman dedicated to ending it.Īthena is an Audio Anamatronic android girl built by Plus Ultra, a secret organization dedicated to one cause: to make a better world. ![]() ![]() ![]() Add her to your feed right now! Like many models, Selter not only starts trends, but she also follows them. With over 12.8 million followers, she is one of the hottest and most successful Instagram models of all time. As if being a sensational fitness model weren’t enough, she also serves as a creative director for an athletic jewelry brand, co-owns a health shake company, and has founded multiple brands that create sugar-free protein bars. Jen Selter has always had a deep passion for fitness and health. To all our Active Instagram Followers, check this out! 1. Create an Instagram account and give it an initial boost by buying Instagram followers from reputable platforms like Socialwick that provide top notch followers and other Instagram services that will guarantee you get the attention you need to become one of the hottest models on the platform. If you think you have what it takes and want to join the list, don’t wait. If there’s a model you don’t see on this list who you think should be here, just let us know! 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New employee behaviors refers to the process of encouraging and identifying behaviors that are viewed as beneficial to company culture and the onboarding process. įinally, employees are segmented based on Employee experience levels as it has a material effect on understanding and ability to assimilate into a new role. Curiosity is believed to play a substantial role in the newcomer adaptation process and is defined as the "desire to acquire knowledge" that energizes individual exploration of an organization's culture and norms.This type of personality is considered beneficial for employees in helping them to better adapt to the organization and become high-functioning organizational members, as well as increasing satisfaction and performance. Proactive personality is the tendency to take charge of situations and achieve control over one's environment.New employee characteristics attempt to identify key personality traits in onboarding employees that the business views as beneficial: Researchers separate the process of onboarding into three parts: new employee characteristics, new employee behaviors, and organizational efforts. The term "onboarding" is management jargon coined in the 1970s. These include higher job satisfaction, better job performance, greater organizational commitment, and reduction in occupational stress and intent to quit. ![]() Studies have documented that socialization techniques such as onboarding lead to positive outcomes for new employees. This process is known in other parts of the world as an 'induction' or training. Tactics used in this process include formal meetings, lectures, videos, printed materials, or computer-based orientations that outline the operations and culture of the organization that the employee is entering into. In the United States, up to 25% of workers are organizational newcomers engaged in onboarding process. In standard English, this is referred to as "induction". Onboarding or organizational socialization is the American term for the mechanism through which new employees acquire the necessary knowledge, skills, and behaviors to become effective organizational members and insiders. ( November 2018) ( Learn how and when to remove this template message)Ī model of onboarding (adapted from Bauer & Erdogan, 2011) See Wikipedia's guide to writing better articles for suggestions. Set the environmentId in the storeDetails object.This article's tone or style may not reflect the encyclopedic tone used on Wikipedia. To use Live Search with PWA Studio, integrators must also: Filtering directly on description, name, short_description is not supported by GraphQL when used with PWA, but they are returned with a more general filter.Intelligent merchandising will not work because of this. Live Search in PWA does not support event handling.The current PWA implementation of Live Search requires more processing time to return search results than Live Search with the native Commerce storefront.There may also be performance differences. Basic functionality such as search and product listing page work in Venia but some permutations of Graphql may not work correctly. Live Search works with PWA Studio but users may see slight differences compared to other Commerce implementations. Live Search customers can use the new SaaS price indexer, which provides faster price change updates and synchronization time. Live Search can manage up to 200 synonyms per store view.Maximum number of events per rule is 25.Maximum number of conditions per rule is 10.Maximum number of rules per store view is 50.To restrict products to the Not Logged In customer group, go to each category and set permission for each customer group.The “Not Logged in” customer group must be given “Allow” browsing permissions.Products must be assigned to the Root category.To restrict customer groups using Catalog permissions: Although similar to the GraphQL API, there are a few differences and some fields may not be fully compatible. Live Search uses a unique GraphQL endpoint for queries to support features such as dynamic faceting and search-as-you-type.Live Search does not have access to the full taxonomy of the category tree, which makes some layered navigation search scenarios beyond its reach.Products must be in the Default Shared Catalog.Indexes only products from the Adobe Commerce database.Indexes up to 300 product attributes per store view.Onboarding flowĬurrently, the Live Search search/category API has the following supported limits and static boundaries: Indexing To get started using Live Search for Adobe Commerce, complete the onboarding process to install the extension, configure your API keys, and synchronize your catalog. If you like how shroud’s crosshair looks, but want to make slight adjustments to fit your preferences, check out our guide on crosshair commands! Shroud’s Crosshair Config However, a large crosshair isn’t necessarily a bad thing, as shroud has proven its success multiple times on the big stages! It is also important to note that shroud prefers a larger crosshair compared to other professional players who prefer smaller crosshairs. Shroud uses a rather basic crosshair, with light blue being the crosshair’s primary color. ![]() Let’s check out what crosshair shroud uses in order to hit insane headshots all the time. If you like all of these settings except for the mouse sensitivity, you can always change it up yourself by checking out our article about sensitivity in CS2! Shroud CS Crosshair SettingsĪ professional player’s crosshair is arguably the most sought out setting that people look for. These mouse settings could explain how he can quickly flick and get those crispy headshots! This puts his eDPI at 1080, which places him on the higher side of the eDPI charts even though he isn’t an AWPer. However, to balance out his effective DPI, shroud uses a high mouse sensitivity of 2.4. Shroud’s DPI is definitely on the lower side, at 450. Paired up with that mouse, let’s check out what mouse settings shroud uses! DPI Shroud uses the Logitech G303 Shroud Edition, which is his own custom style of the popular G303 Logitech gaming mouse. If you’re looking to follow in the footsteps of shroud, then this article has got you covered! Check out all of shroud’s CS2 settings below! Shroud CS Mouse Settings However, people still remember his incredible achievements and display of skill during his professional Counter Strike Global Offensive player days. He is now one of the largest FPS streamers in the entire world, and has moved to Valorant. READ MORE: Shroud’s new US$9.Michael “shroud” Grzesiek is a retired professional Counter Strike Global Offensive player who has made a huge name for himself during his time competing. It’s a way for us to keep the site running and provide you with valuable content. This means if you click on them and make a purchase, we may earn a small commission at no additional cost to you. Just a heads up, some of the links on ONE Esports are affiliate links. GET YOURS TODAY: Nvidia GeForce RTX 3090.What graphics settings does Shroud use? PC GRAPHICS Shroud bought a pair of designer dessert spoons for US$500 each Shroud blew his Mixer money on private jets and… a private island? ![]() Shroud reveals his own brand new game - Project Astrid Shroud reveals his list of Valorant skins that won’t put you at a disadvantage Order the Alienware AW2721D 360Hz gaming monitor used by Shroud hereĭot or not? Shroud explains why you should avoid using dot crosshair in Valorant What monitor settings does Shroud use? Credit: Shroud, ONE Esports MONITOR SETTINGS What radar settings does Shroud use? 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![]() Meier worked back and forth with Shelley to refine this prototype before presenting it to the company in full to bring to a full release, which became the first Civilization game, published in September 1991. Meier brainstormed upon his idea of combining global conquest inspired by Risk, city management from the early Empire games, and adding in the concept of a technology tree. They first created Railroad Tycoon in 1990, inspired by Shelley's work at producing Avalon Hill's 1830: The Game of Railroads and Robber Barons, inspired by Francis Tresham's 1829. He worked with a recent hire, Bruce Shelley, a former board game designer from Avalon Hill, to craft new god games. Meier considered these games demonstrations that video games did not need to be about destruction all the time. Around 1989, Meier wanted to start developing new types of games to expand his repertoire, inspired by the recent successes of the god games SimCity (1989) and Populous (1989). Sid Meier and Bill Stealey co-founded MicroProse in 1982 to develop a number of flight simulators and military strategy software titles. History ĭevelopment at MicroProse (1989–1996) According to 2K Games, a Take-Two subsidiary, the series has shipped more than 51 million total units as of July 2023. Some issues associated with the Civilization name, due to the 1980 Civilization board game created by Francis Tresham, arose during the late 1990s but have been resolved through agreements, settlements, and publishing company acquisitions presently Take-Two, the parent company of Firaxis, owns full rights to both the name and intellectual property for the series. Over the years, some of the crew involved in developing the series became successful in producing their own strategy games, such as Bruce Shelley ( Civilization co-designer) of Age of Empires fame, Brian Reynolds ( Civilization II lead designer and programmer), who went on to create Rise of Nations, and Soren Johnson ( Civilization III co-designer and Civilization IV lead designer and programmer), who worked on Spore and Offworld Trading Company. After MicroProse was acquired by Spectrum Holobyte, Meier left with other designers to form Firaxis Games in 1996, which has been the principal developer of the series since. ![]() The series was first developed by Meier while at MicroProse, the studio he co-founded. Newer games often include extendable downloadable content that adds to that game, and often will become part of the new features in the next main game of the series. Meier had adapted an approach for each new title so that it contains a third of existing features, another third that are improvements from the previous game, and the remaining third as introducing new features. Later games have introduced gameplay concepts and victories based on religion, economics, and diplomacy. In most games in the series, one may win by military conquest, achieving a certain level of culture, building an interstellar space ship, or achieving the highest score, among other means. These reflect the cultural, intellectual, and technical sophistication of the civilization, and usually allow the player to build new units or to improve their cities with new structures. The player will also choose technologies to research. Each turn allows the player to move their units on the map, build or improve new cities and units, and initiate negotiations with the human or computer-controlled players. ![]() The series is considered a formative example of the 4X genre, in which players achieve victory through four routes: "eXplore, eXpand, eXploit, and eXterminate".Īll titles in the series share similar gameplay, centered on building a civilization on a macro-scale from prehistory up to the near future. ![]() There are six main games in the series, a number of expansion packs and spin-off games, as well as board games inspired by the video game series. Sid Meier developed the first game in the series and has had creative input for most of the rest, and his name is usually included in the formal title of these games, such as Sid Meier's Civilization VI. Amiga, Atari ST, SNES, Microsoft Windows, Linux, Mac OS, PlayStation, Nintendo Switch, PlayStation 4, Xbox One, Xbox 360, PlayStation 3, iOS, Android, Nintendo DS, N-Gage, Windows Phone, Facebook Platform, PlayStation Vita, Sega SaturnĬivilization is a series of turn-based strategy video games, first released in 1991. ![]() You won’t find tabby patterns with multiple colors, though. Brown tabbies are the most common, but any color is possible. For instance, a cat may be a brown tabby, which would mean that their stripes are dark brown and the rest of their body is a light brown. There is typically one color that dominates a tabby’s coat. The ticked tabby is similar to the spotted tabby, but with even smaller spots.Īny of these types of tabbies can come in any color. The spotted tabby has spots in a line pattern instead of solid lines. You also have the mackerel tabby, which has smaller and thinner stripes. These cats can come in any tabby coloring, which has many different forms.įor instance, you have the classic tabby pattern, which is what most people think of when they imagine a tabby cat. This is likely the most common type of Domestic Shorthair color. Tabby Colors Image Credit: Thewonderalice, Unsplash These cats are often black where their hair is thickest, while their stomach, neck, and other areas with less fur tend to be gray or white.Ģ. Smoke colorations are also common, which basically is a black coat with white roots. If they come in a color like blue or lilac, there is likely a purebred cat somewhere in their ancestry. After all, they won’t belong to any particular cat breed.įor this reason, these cats can come in any solid color, even those that are a bit rare. When you combine a Domestic Shorthair with another shorthaired cat, all the kittens are technically Domestic Shorthairs. Typically, it is the result of mixed breeding. Many of these are actually British Shorthairs, but you will find this gene in the Domestic Shorthair population as well. Instead, you’re much more likely to find a fawn, white, or black cat.īlue cats are uncommon as well. For instance, chocolate and lilac Domestic Shorthairs are somewhat uncommon. Some are a bit rare because they are more commonly seen in specific breeds. These cats can technically come in any solid color. The 8 Common Domestic Shorthair Cat Colors 1. There are no restrictions on how these cats may look, as long as they have short hair and don’t belong to any particular cat breed. ![]() Since this cat does not have a breed standard, technically any color is allowed. They are typically known as the “generic” cat breed because there isn’t anything particularly different about them. These cats are some of the most common in the United States. They are different from other shorthaired breeds, like the British Shorthair and the American Shorthair, because these cats are not recognized by any particular cat organization and do not have a breed standard. The Domestic Shorthair is a shorthaired cat that does not belong to any particular cat breed. Composer/:, Ronny Svendsen, Anne Judith Stokke Wik, Bobii Lewis. Lyrics/: (JQ), DADA (makeumine works), Tommy trate. It’s a sly little hook almost more of a taunt than a fully fleshed. Every time Simon Says loops back to the slurred harmonics of its chorus, the song gains renewed focus and energy. Simon first rose to musical acclaim in the 1960s as one half of the duo Simon & Garfunkel, before he went on to have an award-winning solo career. Taeil, Johnny, Taeyong, Yuta, Doyoung, Jaehyun, Winwin, Jungwoo, Mark, Haechan. It relies on the kind of catchphrase hooks that feel better suited to memes that pop songs, but it’s anchored by one addictive refrain. Simon Cowell Says His Son, 8, Helped Him Find Balance: Before Eric, My Life Was 99 Percent Work Thats going to be total torture,' Cowell continued, joking. “You know, something happens to you when you have some sort of disability that changes your awareness or changes how you interact with life.” ![]() If I’m feeling … ‘whatever.’ So it’s a very crucial thing to me,” he said. ![]() “It’s the instrument that allows me to express myself creatively. While in Toronto, Simon said he still plays his guitar daily. My reaction to that was frustration and annoyance not quite anger yet, because I thought it would pass, it would repair itself.”Īs a result, performing live has been a challenge. “Quite suddenly I lost most of the hearing in my left ear, and nobody has an explanation for it,” he said at the time. ![]() Simon first that he had gone mostly deaf in his left ear in an interview with The Times UK back in May. “I haven’t accepted it entirely, but I’m beginning to,” Simon reportedly said of his hearing loss while on stage with the film’s director, Alex Gibney. Simon, who has lost most of his hearing in his left ear, addressed that challenge during a post-screening Q&A for the documentary “In Restless Dreams: The Music of Paul Simon” at the Toronto International Film Festival, according to The Hollywood Reporter. It’s only been a few months since legendary singer Paul Simon went public with his hearing loss and he now says he’s still adjusting. ![]() They also worry that unforeseen consequences could reduce catches and trigger government limits on how much can be caught if fish stocks diminish.Īnd while some companies have voluntarily agreed to compensate fishermen for any economic damage, there is no mandate requiring it. They worry about being able to safely navigate around the turbines, and about being prohibited from productive fishing grounds on which they have relied for generations. ![]() They fear electromagnetic fields emitted from underwater power cables could deter or harm some marine life. Interviews with commercial and recreational fishermen and women show they share common anxieties about the offshore wind turbines chasing away species they have long relied on. fishing industry - both commercial and recreational - has numerous concerns about offshore wind impacting operations in places long available for fishing with minimal interference. But three federal agencies say there is no evidence the two are related. Opponents blame ocean floor preparation for causing or contributing to the deaths of 70 whales on the U.S. Phil Sgro, a spokesman for the American Clean Power Association, said the industry believes sufficient scientific studies exist to establish that offshore wind development can be done “in a manner that is both economical and environmentally responsible.” Bureau of Ocean Energy Management has posted a half-dozen or more studies on its web site every year since 2016 in several instances the studies called for further investigation and analysis. ![]() The request was made “in support of the rapid development of offshore wind,” according to a notice on the website. Others, including flatfish and whiting, were shown to leave those areas.Īnd in May, the Biden Administration offered an $850,000 grant to collect more information on the hearing abilities of critically endangered North American right whales, citing “knowledge gaps” in how the animals behave. Some European studies have shown that crabs and lobster are attracted to harder sea bottoms that support wind turbines. Research in other countries also is also nuanced. He said the work helps agencies define monitoring required for long-term studies and that more work is required to determine how offshore wind energy changes marine habitats. Andy Lipsky, who oversees the wind energy team at NOAA’s Northeast Fisheries Science Center, is a co-author. In most instances, report authors agreed that more studies are needed. At the same time, cloudy water from turbine operations, noise, vibrations and electromagnetic fields could also make species leave an area. The March study said large underwater platforms are rapidly colonized by smaller, bottom-dwelling marine life, including shellfish and crabs, which in turn attract larger predators like black sea bass. For instance, turbines can attract some fish and repel others. Like numerous existing studies, the report pointed out the complexities of how the structures and cables might interact with marine life. A joint study in March by two federal scientific agencies and the commercial fishing industry documents numerous impacts that offshore wind power projects could have on fish and marine mammals, including noise, vibration, electromagnetic fields and heat transfer that could alter the environment. ![]() ![]() If your Windows 10 system lacks certain audio codecs, you probably won’t be able to rip music to your computer (you probably won’t be able to even play it). Go to File, Manage Libraries, and then to Musicĭelete all music libraries except the default one, where your music will be placed I understand that you are unable to burn. Should the inability of Windows Media Player to burn wav music files be by design without any solution, I would appreciate knowing this, so additional time is not expended trying to find a solution that is not, at least, at present available. It would be appreciated to know what is required to restore the interface between Windows 10 and it's Windows Media Player so it will burn wav music files on a blank cd as was previous usual practice?Īre there any Windows 10 updates that would restore this function? So, the Windows Media Player code is not corrupted. There was no change in the notebook's inability to burn a cd from wav files. Windows Media Player on the notebook was uninstalled and then a clean version installed. It is important to note here that the new notebook replaces a 2003 desktop with Windows XP and its Windows Media Player works perfectly in burning these playlists in the wav format. The idea is to burn the entire playlist and not what is left on a random basis. If I remove these songs from the burn list, it may burn the remaining playlist. If I rearrange the burn list with the same songs and go through the burn process, different songs will come up with the white x in the red circle. From the error message, I followed instructions and clicked on "Blank Disk (E)" and 5 or 6 songs in the burn list come up with the white x in the red circle. The problem is that Windows Media Player will not start to burn the burn list on a blank cd. Using Windows Media Player, I ripped a number of Christmas cds I have in the wav format to make a burn list of my favourites. ![]() I have a new HP notebook with Windows 10 and it also contains an optical drive. Business PCs, Workstations and Point of Sale Systems.Printer Wireless, Networking & Internet.DesignJet, Large Format Printers & Digital Press.Printing Errors or Lights & Stuck Print Jobs.Notebook Hardware and Upgrade Questions. |
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